Scube 2 enhances proteolytic Shh processing from the surface of producing cells 1 2
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چکیده
Scube2 enhances proteolytic Shh processing from the surface of producing cells 1 2 Petra Jakobs*, Sebastian Exner*, Sabine Schürmann*, Ute Pickhinke, Shyam 3 Bandari, Corinna Ortmann, Sabine Kupich, Philipp Schulz, Uwe Hansen, Daniela G. 4 Seidler & Kay Grobe 5 6 From the Institute for Physiological Chemistry and Pathobiochemistry, Westfälische 7 Wilhelms Universität Münster, Waldeyerstr. 15, D-48149 Münster, Germany. 8 *: equal contribution 9 10 Running title: Scube-activated Sonic hedgehog shedding 11 12
منابع مشابه
Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells.
All morphogens of the Hedgehog (Hh) family are synthesized as dual-lipidated proteins, which results in their firm attachment to the surface of the cell in which they were produced. Thus, Hh release into the extracellular space requires accessory protein activities. We suggested previously that the proteolytic removal of N- and C-terminal lipidated peptides (shedding) could be one such activity...
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All Hedgehog morphogens are released from producing cells, despite being synthesized as N- and C-terminally lipidated molecules, a modification that firmly tethers them to the cell membrane. We have previously shown that proteolytic removal of both lipidated peptides, called shedding, releases bioactive Sonic hedgehog (Shh) morphogens from the surface of transfected Bosc23 cells. Using in vivo ...
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